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Analysis of Biopolymers with Laser Diffraction

Particle Characterization

Considerable research has been conducted exploring the use of nanoparticles composed of biopolymers as a drug delivery vehicle. Since the design goal for nanoparticles is in the range of 100 nm, much of the particle size analysis in this field has been done using dynamic light scattering (DLS). However, certain materials will feature larger particles that are outside the upper size range of DLS, but within the capability of laser diffraction. Therein is the unique value of a single analyzer that can accurately measure particles both less than 100 nm and greater than several microns. This application note describes two experiments where laser diffraction proved capable of determining both the base biopolymer nanoparticles and also larger particles outside of the range of DLS.

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Analysis of Biopolymers with Laser Diffraction
The LA-960 is capable of detecting both nano-scaled particles smaller than 100 nm in addition to larger model or agglomerated particles. This highlights several unique capabilities including the low end dynamic range to measure down to 30 nm via laser diffraction, the ability to accurately split multiple populations, and the sensitivity to detect a small percentage of agglomerates in the presence of a main peak in the nanoparticle range.
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