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Particle characterization of pharmaceutical
One of the most important performance factors of a pharmaceutical product is the bioavailability, i.e. the release of the active compound in a human body.
For the study of a pharmaceutical drug product, particle characteristics (count, size and chemistry) and compound distributions (size and spatial) are among key parameters that strongly determine the quality of the product due to their huge impact on the dissolution rate (and thus bioavailability) for the final solid dosage form. Monitoring these characteristics is critical in raw materials, interim mixtures during processing, and final products. In this application note, a powder mixture similar to an interim mixture of a pharmaceutical product was used. Laser diffraction and Raman microscopy were applied to highlight the benefits of combining two technologies for particle characterization.
MicroRaman Spectrometer - Confocal Raman Microscope
Laser Scattering Particle Size Distribution Analyzer
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